Development of cell-permeable peptide-based PROTACs targeting estrogen receptor α

Volume: 187, Pages: 111967 - 111967
Published: Feb 1, 2020
Abstract
Proteolysis-targeting chimera (PROTAC) could selectively degrade target protein and may become a promising strategy for treating estrogen receptor α (ERα) positive breast cancers. Here, we designed penetrated peptide-based PROTACs by constructing an N-terminal lactam cyclic to improve proteolytic stability and cell penetration. We used a lactam cyclic peptide as ERα binding ligand, 6-aminocaproic acid as a linker, and a hydroxylated pentapeptide...
Paper Details
Title
Development of cell-permeable peptide-based PROTACs targeting estrogen receptor α
Published Date
Feb 1, 2020
Volume
187
Pages
111967 - 111967
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