HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity
Abstract
Pharmacologic HIF hydroxylase inhibitors (HIs) are effective for the treatment of anemia in chronic kidney disease patients and may also be beneficial for the treatment of diseases such as chronic inflammation and ischemia-reperfusion injury. The selectivities of many HIs for HIF hydroxylases and possible off-target effects in cellulo are unclear, delaying the translation from preclinical studies to clinical trials. We developed a novel assay...
Paper Details
Title
HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity
Published Date
Dec 19, 2019
Journal
Volume
34
Issue
2
Pages
2344 - 2358
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