Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity
Abstract
PDGF/VEGF ligands regulate a plethora of biological processes in multicellular organisms via autocrine, paracrine and endocrine mechanisms. Here, we investigated organ-specific roles of Drosophila PDGF/VEGF-like factors (Pvfs). We combine genetic approaches and single-nuclei sequencing to demonstrate that muscle-derived Pvf1 signals to the Drosophila hepatocyte-like cells/oenocytes to suppress lipid synthesis by activating the Pi3K/Akt1/mTOR...
Paper Details
Title
Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity
Published Date
Mar 18, 2020
Journal
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