Internalization of microparticles by platelets is partially mediated by toll-like receptor 4 and enhances platelet thrombogenicity

Background and aims Circulating platelet microparticles (PMP) are the most abundant in bloodstream, are highly procoagulant and contribute to cross-talk with inflammatory cells. The aim of the present study was to investigate the interactions of PMP with platelets and explore the involvement of toll-like receptor 4 (TLR-4). Methods PMP were separated by ultracentrifugation of expired platelet concentrates and added to: i) washed platelets, to...