Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats
Abstract
Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). This study examined the dependence-producing effects of MG using operant-scheduled behaviour in rats and investigated the potential therapeutic effect of MG by comparing effects to buprenorphine in morphine-dependent rats using the same...
Paper Details
Title
Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats
Published Date
Dec 12, 2019
Journal
Volume
237
Issue
3
Pages
855 - 867
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Notes
History