Targeted genome sequencing of negative and positive human papillomavirus induced conjunctival carcinomas

Purpose To perform a comprehensive targeted genome sequencing of premalignant and malignant conjunctival squamous cell carcinomas in order to elucidate the genetic background of these tumours. Methods Due to the scant knowledge of the mutational landscape in conjunctival carcinomas, we performed next‐generation sequencing of 509 genes commonly affected in human cancers. We sequenced a total of 110 tumours; 31 invasive carcinomas, 55 preinvasive...