What is the Optimal Preoperative Imaging Modality for Assessing Peritoneal Cancer Index? An Analysis From the United States HIPEC Collaborative.

Published on Mar 1, 2020in Clinical Colorectal Cancer3.176
· DOI :10.1016/J.CLCC.2019.12.002
Rachel M. Lee1
Estimated H-index: 1
(Emory University),
Mohammad Y. Zaidi4
Estimated H-index: 4
(Emory University)
+ 25 AuthorsMaria C. Russell16
Estimated H-index: 16
(Emory University)
Abstract Background Radiographic prediction of PCI can improve patient selection for cytoreductive surgery. We aimed to determine the correlation of CT-predicted PCI (CT-PCI) and MRI-predicted PCI (MRI-PCI) with intraoperative-PCI, and if a preoperative-PCI cutoff is associated with incomplete cytoreduction. Patients and Methods Patients from the US HIPEC Collaborative (2000-17) with appendiceal, colorectal, or peritoneal mesothelioma (PM) histology who underwent cytoreductive surgery were included. Pearson correlation coefficients were used to determine correlation between preoperative and intraoperative-PCI values. Fisher r-to-z transformation was used to compare correlations. Results 488 patients were included. 34% had non-invasive appendiceal, 30% invasive appendiceal, 28% colorectal, and 8% PM histology. CT-PCI was correlated with intraoperative-PCI for patients with non-invasive and invasive appendiceal, and colorectal histologies (r=0.689, 0.554, 0.571; all p Conclusions In this multi-institutional cohort, CT and MRI-PCI correlate well with intraoperative-PCI. MRI appears to be superior for invasive appendiceal and peritoneal mesothelioma. External validation in a larger population is needed.
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