RosettaGPCR: Multiple Template Homology Modeling of GPCRs with Rosetta

Published: Dec 13, 2019
Abstract
G-protein coupled receptors (GPCRs) represent a significant target class for pharmaceutical therapies. However, to date, only about 10% of druggable GPCRs have had their structures characterized at atomic resolution. Further, because of the flexibility of GPCRs, alternative conformations remain to be modeled, even after an experimental structure is available. Thus, computational modeling of GPCRs is a crucial component for understanding...
Paper Details
Title
RosettaGPCR: Multiple Template Homology Modeling of GPCRs with Rosetta
Published Date
Dec 13, 2019
Journal
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