Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?
Abstract
The DNA damage response (DDR) machinery is responsible for detecting DNA damage, pausing the cell cycle and initiating DNA repair. Ataxia telangiectasia and Rad3-related (ATR) protein is a key kinase at the heart of the DDR, responsible for sensing replication stress (RS) and signalling it to S and G2/M checkpoints to facilitate repair. In cancer, loss of G1 checkpoint control and activation of oncogenes that drive replication, result in cancer...
Paper Details
Title
Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?
Published Date
Mar 1, 2020
Journal
Volume
207
Pages
107450 - 107450
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