SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors
Abstract
Growth and patterning of the cerebellum is compromised if granule cell precursors do not properly expand and migrate. During embryonic and postnatal cerebellar development, the Hedgehog pathway tightly regulates granule cell progenitors to coordinate appropriate foliation and lobule formation. Indeed, granule cells impairment or defects in the Hedgehog signaling are associated with developmental, neurodegenerative and neoplastic disorders. So...
Paper Details
Title
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors
Published Date
Dec 23, 2019
Journal
Volume
9
Issue
1
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