Cortical Surfaces Mediate the Relationship Between Polygenic Scores for Intelligence and General Intelligence
Abstract
Recent large-scale, genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with general intelligence. The cumulative influence of these loci on brain structure is unknown. We examined if cortical morphology mediates the relationship between GWAS-derived polygenic scores for intelligence (PSi) and g-factor. Using the effect sizes from one of the largest GWAS meta-analysis on general intelligence to date, PSi...
Paper Details
Title
Cortical Surfaces Mediate the Relationship Between Polygenic Scores for Intelligence and General Intelligence
Published Date
Dec 11, 2019
Journal
Volume
30
Issue
4
Pages
2708 - 2719
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