Programmed death ligand 2 – A link between inflammation and bone loss in rheumatoid arthritis
Abstract
Active rheumatoid arthritis (RA) is accompanied by increased appendicular and axial bone loss, closely associated to the degree of inflammation. The programmed death-1 (PD-1) pathway is important for maintaining peripheral tolerance, and its ligand PD-L2 has recently been associated with bone morphogenetic protein activity. Here, we report that PD-L2 plays a central role in RA osteoimmunology. Femoral bone mineral density (BMD) and trabecular...
Paper Details
Title
Programmed death ligand 2 – A link between inflammation and bone loss in rheumatoid arthritis
Published Date
Jan 1, 2020
Volume
3
Pages
100028 - 100028
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