Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

Cell64.50
Volume: 180, Issue: 1, Pages: 92 - 106
Published: Jan 9, 2020
Abstract
Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses that are higher in magnitude and affinity than the primary response. These involve reengagement of memory B cell (MBC) clones, the diversity and specificity of which determine the breadth and effectiveness of the ensuing antibody response. Using prime-boost models in mice, we find that secondary responses are characterized by a clonality bottleneck that...
Paper Details
Title
Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting
Published Date
Jan 9, 2020
Journal
Volume
180
Issue
1
Pages
92 - 106
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