Pembrolizumab as a Cause of Cholangiopathy in a Patient With Metastatic Melanoma

Published on Jun 1, 2020in Hepatology14.971
· DOI :10.1002/HEP.31089
Laura Stuart1
Estimated H-index: 1
(Newcastle University),
Beth Lambourne1
Estimated H-index: 1
(Newcastle upon Tyne Hospitals NHS Foundation Trust)
+ 4 AuthorsJessica K. Dyson15
Estimated H-index: 15
(Newcastle University)
Programmed cell death protein 1 receptor (PD-1) is a cell surface protein involved in immune response regulation. Pembrolizumab is a monoclonal antibody against PD-1 and used to treat patients with stage IV and III melanoma.(1) Immune-related hepatotoxicity is reported in 2-10% of patients(2) with case reports of vanishing bile duct syndrome(3), subacute biliary injury and immune cholangitis.(4).
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