Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
Abstract
Single-strand breaks (SSBs) represent the major form of DNA damage, yet techniques to map these lesions genome-wide with nucleotide-level precision are limited. Here, we present a method, termed SSiNGLe, and demonstrate its utility to explore the distribution and dynamic changes in genome-wide SSBs in response to different biological and environmental stimuli. We validate SSiNGLe using two very distinct sequencing techniques and apply it to...
Paper Details
Title
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
Published Date
Dec 20, 2019
Journal
Volume
10
Issue
1
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