Match!

Impact of Single-organ Metastasis to the Liver or Lung and Genetic Mutation Status on Prognosis in Stage IV Colorectal Cancer.

Published on Mar 1, 2020in Clinical Colorectal Cancer3.176
路 DOI :10.1016/j.clcc.2019.12.001
Paul Cavallaro6
Estimated H-index: 6
(Harvard University),
Liliana Bordeianou24
Estimated H-index: 24
(Harvard University)
+ 6 AuthorsRocco Ricciardi26
Estimated H-index: 26
(Harvard University)
Abstract
Abstract Background The impact of primary tumor site on overall survival in stage IV colorectal cancer (CRC) patients with single-organ metastases to the liver or lung has not been studied. Furthermore, the prognostic significance of commonly tested genetic variants such as KRAS mutation and microsatellite instability (MSI) are not well-described in this population. Methods This National Cancer Database was used to identify 38,328 patients with CRC that presented with synchronous metastases to the liver or lung between 2010 and 2014. The primary outcome was overall survival, and groups were compared using Kaplan-Meier analyses and Cox proportional hazard models. Results On unadjusted analysis, median survival was significantly longer for patients with lung metastases compared to liver metastases for left-sided (27 vs 25 months, p=0.02) and right-sided CRC (19 vs 15 months, p Conclusions For patients with single-organ metastases to the liver or lung, primary tumor site has an impact on overall survival. Further, KRAS mutation and MSI status are of prognostic importance in selected patients with single-organ metastases.
  • References (26)
  • Citations (1)
馃摉 Papers frequently viewed together
9 Citations
2 Citations
13 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References26
Newest
#1Hendrik Bl盲ker (Charit茅)H-Index: 29
#2Elizabeth Alwers (DKFZ: German Cancer Research Center)H-Index: 3
Last. Michael Hoffmeister (DKFZ: German Cancer Research Center)H-Index: 43
view all 12 authors...
Abstract Background & Aims Colorectal tumors with mutations in BRAF and microsatellite stability (MSS) have been associated with adverse outcomes of patients. Combined tests for microsatellite instability (MSI-H) and BRAF mutations might therefore be used in risk assessment, particularly for patients with stage II tumors. We investigate the stage-specific prognostic value of combined testing for MSI-H and BRAF for patients with colorectal cancer (CRC). Methods We performed a retrospective analys...
5 CitationsSource
#1Lin YangH-Index: 5
Last. Liangping XiaH-Index: 8
view all 10 authors...
Source
#1Thiru Prasanna (Canberra Hospital)H-Index: 2
#2Christos S. Karapetis (Flinders Medical Centre)H-Index: 30
Last. Desmond Yip (ANU: Australian National University)H-Index: 23
view all 16 authors...
AbstractBackground: Pattern of spread in patients with metastatic colorectal cancer (mCRC) is variable and may reflect different biology in subsets of patients. This is a retrospective study to explore the outcome of patients with mCRC based on their site of metastasis at diagnosis and to explore the association between tumor characteristics [KRAS/RAS, BRAF, mismatch repair (MMR) status, site of primary] and the site of metastasis.Methods: Patients from two Australian databases were divided into...
10 CitationsSource
#1Camille L. StewartH-Index: 1
#2Susanne G. WarnerH-Index: 7
Last. Yuman FongH-Index: 109
view all 8 authors...
1 CitationsSource
#1Hagen F. Kennecke (UBC: University of British Columbia)H-Index: 23
#2Yaling YinH-Index: 3
Last. Richard M. Lee-Ying (TBCC: Tom Baker Cancer Centre)H-Index: 3
view all 6 authors...
2 CitationsSource
#1Dakui Luo (Fudan University)H-Index: 3
#2Qi Liu (Fudan University)H-Index: 3
Last. Xinxiang Li (Fudan University)H-Index: 11
view all 9 authors...
Purpose We investigated the prognostic value of distant metastasis sites among patients with metastatic colorectal cancer (CRC) and the significance of metastasectomy and resection of the primary CRC.
7 CitationsSource
#1Katsumi AmikuraH-Index: 7
#2Kiwamu AkagiH-Index: 15
Last. Hirohiko SakamotoH-Index: 13
view all 5 authors...
4 CitationsSource
#1J. Engstrand (KI: Karolinska Institutet)H-Index: 3
#2Henrik Nilsson (KI: Karolinska Institutet)H-Index: 10
Last. Jacob Freedman (KI: Karolinska Institutet)H-Index: 18
view all 5 authors...
Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25鈥30% of those affected. Previous data suggest a survival difference between right- and left-sided liver metastatic CRC, even though left-sided cancer has a higher incidence of liver metastases. The aim of the study was to describe the liver metastatic patterns and survival as a function of the characteristics of the primary tumour and different combinations of metastatic disease. A retros...
31 CitationsSource
#1Mary E. Charlton (UI: University of Iowa)H-Index: 15
#2Amanda R. Kahl (UI: University of Iowa)H-Index: 2
Last. Vivien W. Chen (LSU: Louisiana State University)H-Index: 42
view all 7 authors...
4 CitationsSource
#1Dirk ArnoldH-Index: 8
#2Lueza B (University of Paris-Sud)H-Index: 1
Last. Fortunato Ciardiello (Seconda Universit脿 degli Studi di Napoli)H-Index: 75
view all 12 authors...
Background: There is increasing evidence that metastatic colorectal cancer (mCRC) is a genetically heterogeneous disease and that tumours arising from different sides of the colon (left versus right) have different clinical outcomes. Furthermore, previous analyses comparing the activity of different classes of targeted agents in patients with KRAS wild-type (wt) or RAS wt mCRC suggest that primary tumour location (side), might be both prognostic and predictive for clinical outcome. Methods: This...
154 CitationsSource
Cited By1
Newest
#1Yinghao Cao (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Shenghe Deng (HUST: Huazhong University of Science and Technology)H-Index: 1
Last. Kailin Cai (HUST: Huazhong University of Science and Technology)H-Index: 6
view all 7 authors...
PURPOSE: Perineural invasion (PNI) is associated with poor prognosis in a variety of cancers. Our aim was to determine the clinicopathological factors associated with PNI in colorectal cancer (CRC) and its impact on patient survival. MATERIAL AND METHODS: The clinical data of 1412 patients diagnosed with CRC from July 2013 to July 2016 were retrospectively collected. PNI was determined based on hematoxylin-eosin staining. The relationships of PNI with various clinicopathological factors and prog...
Source