Molecular structures and mechanisms of DNA break processing in mouse meiosis

Published: Dec 17, 2019
Abstract
Exonucleolytic resection, critical to repair double-strand breaks (DSBs) by recombination, is not well understood, particularly in mammalian meiosis. Here, we define structures of resected DSBs in mouse spermatocytes genome-wide at nucleotide resolution. Resection tracts averaged 1100 nucleotides, but with substantial fine-scale heterogeneity at individual hotspots. Surprisingly, EXO1 is not the major 5′→3′ exonuclease, but the DSB-responsive...
Paper Details
Title
Molecular structures and mechanisms of DNA break processing in mouse meiosis
Published Date
Dec 17, 2019
Journal
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