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The anti-inflammatory effects of jiangrines from Jiangella alba through inhibition of p38 and NF-κB signaling pathways

Published on Jan 1, 2020in Bioorganic Chemistry3.926
· DOI :10.1016/j.bioorg.2019.103507
Peipei Guan3
Estimated H-index: 3
(NU: Northeastern University),
Xingbo Wang3
Estimated H-index: 3
(NU: Northeastern University)
+ 7 AuthorsCheng-Lin Jiang31
Estimated H-index: 31
(Yunnan University)
Abstract
Abstract Three pyrrol-2-aldehyde derivatives, including one new compound, jiangrine G (JG), two known compounds, jiangrine A (JA), and pyrrolezanthine (PZ), were isolated from the fermentation broth of Jiangella alba associated with a traditional Chinese medicinal plant Maytenus austroyunnanensis. The structure of jiangrine G was elucidated by a detailed spectroscopic data analysis including data from CD spectra. The anti-inflammatory activities assay demonstrated that JG and JA suppressed the production of pro-inflammatory cytokines including NO, IL-1β, and IL-6 as well as inhibited the expression of iNOS in LPS-induced RAW 264.7 cells in a dose-dependent manner. While high concentration of PZ dramatically suppressed the protein expression of TNF-α, but stimulated the release of IL-1β and IL-6. Western blot results revealed that JG, JA, and PZ modulated the expression of pro-inflammatory cytokines via MAPK p38 and NF-κB signaling pathways. For the unique structure of PZ, difference from JG and JA, the signaling pathway involved in mediating its effects on regulating the synthesis of IL-1β and IL-6 are probably more complicated than that of JG and JA.
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