The balancing act of R-loop biology: The good, the bad, and the ugly
Abstract
An R-loop is a three-stranded nucleic acid structure that consists of a DNA:RNA hybrid and a displaced strand of DNA. R-loops occur frequently in genomes and have significant physiological importance. They play vital roles in regulating gene expression, DNA replication, and DNA and histone modifications. Several studies have uncovered that R-loops contribute to fundamental biological processes in various organisms. Paradoxically, although they...
Paper Details
Title
The balancing act of R-loop biology: The good, the bad, and the ugly
Published Date
Dec 16, 2019
Volume
295
Issue
4
Pages
905 - 913
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