Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization.
Abstract
The bone marrow constitutes the primary site for life-long blood production and skeletal regeneration. However, its cellular and spatial organization remains controversial. Here, we combine single-cell and spatially resolved transcriptomics to systematically map the molecular, cellular and spatial composition of distinct bone marrow niches. This allowed us to transcriptionally profile all major bone-marrow-resident cell types, determine their...
Paper Details
Title
Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization.
Published Date
Jan 1, 2020
Journal
Volume
22
Issue
1
Pages
38 - 48
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