Inhibition of XBP1s ubiquitination enhances its protein stability and improves glucose homeostasis

Volume: 105, Pages: 154046 - 154046
Published: Apr 1, 2020
Abstract
Background Hepatic ER stress is a risk factor of insulin resistance and type 2 diabetes. X-box binding protein 1 spliced (XBP1s), a transcription factor, plays a key role in ameliorating insulin resistance and maintaining glucose homeostasis. Unfortunately, the short half-life of the protein dampens its clinical application, and the specific site of lysine residue that could be ubiquitinated and involved in the degradation of XBP1s remains...
Paper Details
Title
Inhibition of XBP1s ubiquitination enhances its protein stability and improves glucose homeostasis
Published Date
Apr 1, 2020
Volume
105
Pages
154046 - 154046
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