Resistance to ceftazidime–avibactam and underlying mechanisms

Ceftazidime–avibactam (CAZ-AVI) is a novel synthetic β-lactamase inhibitor combination. Although the combination has been available clinically for only a few years, cases of resistance to CAZ-AVI have already been reported. In the present review, we summarize the distribution of CAZ-AVI-resistant strains and the possible resistance mechanisms. There are no significant differences in CAZ-AVI resistance rates across different regions. CAZ-AVI...