Role of autophagy in alcohol and drug-induced liver injury

Volume: 136, Pages: 111075 - 111075
Published: Feb 1, 2020
Abstract
Alcohol-related liver disease (ALD) and drug-induced liver injury (DILI) are common causes of severe liver disease, and successful treatments are lacking. Autophagy plays a protective role in both ALD and DILI by selectively removing damaged mitochondria (mitophagy), lipid droplets (lipophagy), protein aggregates and adducts in hepatocytes. Autophagy also protects against ALD by degrading interferon regulatory factor 1 (IRF1) and damaged...
Paper Details
Title
Role of autophagy in alcohol and drug-induced liver injury
Published Date
Feb 1, 2020
Volume
136
Pages
111075 - 111075
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