Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance
Abstract
DNA is susceptible to a range of chemical modifications, with one of the most frequent lesions being apurinic/apyrimidinic (AP) sites. AP sites arise due to damage-induced (e.g. alkylation) or spontaneous hydrolysis of the N-glycosidic bond that links the base to the sugar moiety of the phosphodiester backbone, or through the enzymatic activity of DNA glycosylases, which release inappropriate bases as part of the base excision repair (BER)...
Paper Details
Title
Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance
Published Date
Dec 9, 2019
Journal
Volume
35
Issue
1
Pages
27 - 38
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History