Infection-induced signals generated at the plasma membrane epigenetically regulate Wnt signaling in vitro and in vivo
Abstract
Wnt signaling regulates immunomodulatory functions during infection and inflammation. Employing NCCIT and HCT116 cells, having high endogenous Wnt signaling, we observed elevated levels of low-density lipoprotein receptor–related protein 5/6 (LRP5/6) and Frizzled class receptor 10 (FZD10) and increases in β-catenin, doublecortin-like kinase 1 (DCLK1), CD44 molecule (CD44), and aldehyde dehydrogenase 1 family member A1 (ALDH1A1). siRNA-induced...
Paper Details
Title
Infection-induced signals generated at the plasma membrane epigenetically regulate Wnt signaling in vitro and in vivo
Published Date
Dec 13, 2019
Volume
295
Issue
4
Pages
1021 - 1035
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