Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.
Abstract
Diabetes mellitus affects one in eleven adults worldwide. Most suffer from Type 2 Diabetes which features elevated blood glucose levels and an inability to adequately secrete or respond to insulin. Insulin producing β-cells have primary cilia which are implicated in the regulation of glucose metabolism, insulin signaling and secretion. To better understand how β-cell cilia affect glucose handling, we ablate cilia from mature β-cells by deleting...
Paper Details
Title
Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.
Published Date
Dec 12, 2019
Journal
Volume
10
Issue
1
Pages
5686 - 5686
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