Design, synthesis and interaction of BRC4 analogous peptides with RAD51(241–260)
Abstract
Breast cancer susceptibility gene 2 (BRCA2) is an important tumor suppressor, which is participated in repair of damaged DNA by its highly conserved BRC repeat motifs regulating RAD51 protein homologous recombination and thereby preventing cell carcinogenesis. In this study, the BRCA2(1524–1548)–RAD51(241–260) complex structure was obtained based on PDB bank data 1N0W, which provided the basis for site-specific mutation of BRCA2(1524–1548). The...
Paper Details
Title
Design, synthesis and interaction of BRC4 analogous peptides with RAD51(241–260)
Published Date
Dec 24, 2019
Journal
Volume
52
Issue
3
Pages
361 - 369
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Notes
History