Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis

Sarah Forrester; Karin Siefert; Helen Ashwin; Najmeeyah Brown; Andrea Zelmar; Sally James; Dimitris Lagos; Jon Timmis; Mitali Chatterjee; Jeremy C. Mottram; Simon L. Croft; Paul M. Kaye

doi:https://doi.org/10.12688/wellcomeopenres.15606.1

doi.org/10.12688/wellcomeopenres.15606.1

Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis

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..., Paul M. Kaye

52

Wellcome open research

Volume: 4, Pages: 198 - 198

Published: Dec 10, 2019

Abstract

Background: Liposomal amphotericin B (AmBisome®) as a treatment modality for visceral leishmaniasis (VL) has had significant impact on patient care in some but not all regions where VL is endemic. As the mode of action of AmBisome® in vivo is poorly understood, we compared the tissue-specific transcriptome in drug-treated vs untreated mice with experimental VL. ...

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Paper Details

Title

Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis

DOI

doi.org/10.12688/wellcomeopenres.15606.1

Published Date

Dec 10, 2019

Journal

Wellcome open research

Volume

4

Pages

198 - 198

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