Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

Published: Dec 10, 2019
Abstract
Mitochondrial form and function, such as translation, are closely interlinked in homeostasis and aging. Inhibiting mitochondrial translation is known to increase lifespan in C. elegans , which is accompanied by a fragmented mitochondrial network. However, the causality between mitochondrial translation and morphology in longevity remains uncharacterized. Here, we show in C. elegans that disrupting mitochondrial network homeostasis by either...
Paper Details
Title
Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30
Published Date
Dec 10, 2019
Journal
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