Model of Patient-Specific Immune-Enhanced Organoids for Immunotherapy Screening: Feasibility Study
Abstract
We hypothesized that engineering a combined lymph node/melanoma organoid from the same patient would allow tumor, stroma, and immune system to remain viable for personalized immunotherapy screening. Surgically obtained matched melanoma and lymph node biospecimens from the same patient were transferred to the laboratory and washed with saline, antibiotic, and red blood cell lysis buffer. Biospecimens were dissociated, incorporated into an...
Paper Details
Title
Model of Patient-Specific Immune-Enhanced Organoids for Immunotherapy Screening: Feasibility Study
Published Date
Jun 1, 2020
Journal
Volume
27
Issue
6
Pages
1956 - 1967
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Notes
History