MEK2 is a critical modulating mechanism to down‐regulate GCIP stability and function in cancer cells
Abstract
Loss of tumor suppressor activity and upregulation of oncogenic pathways simultaneously contribute to tumorigenesis. Expression of the tumor suppressor, GCIP (Grap2- and cyclin D1-interacting protein), is usually reduced or lost in advanced cancers, as seen in both mouse tumor models and human cancer patients. However, no previous study has examined how cancer cells down-regulate GCIP expression. In this study, we first validate the tumor...
Paper Details
Title
MEK2 is a critical modulating mechanism to down‐regulate GCIP stability and function in cancer cells
Published Date
Dec 19, 2019
Journal
Volume
34
Issue
2
Pages
1958 - 1969
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