Mate pair sequencing outperforms fluorescence in situ hybridization in the genomic characterization of multiple myeloma
Abstract
Fluorescence in situ hybridization (FISH) is currently the gold-standard assay to detect recurrent genomic abnormalities of prognostic significance in multiple myeloma (MM). Since most translocations in MM involve a position effect with heterogeneous breakpoints, we hypothesize that FISH has the potential to miss translocations involving these regions. We evaluated 70 bone marrow samples from patients with plasma cell dyscrasia by FISH and...
Paper Details
Title
Mate pair sequencing outperforms fluorescence in situ hybridization in the genomic characterization of multiple myeloma
Published Date
Dec 16, 2019
Journal
Volume
9
Issue
12
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