A new zinc chelator, IPZ-010 ameliorates postoperative ileus
Abstract
Zinc was discovered to be a novel second messenger in immunoreactive cells. We synthesized a novel free zinc chelator, IPZ-010. Here, we investigated the effects of IPZ-010 in a mouse postoperative ileus model and determined the effects of zinc signal inhibition as a new therapeutic strategy against postoperative ileus. Zinc waves were measured in bone marrow-derived mast cells (BMMCs) loaded with a zinc indicator, Newport green. Degranulation...
Paper Details
Title
A new zinc chelator, IPZ-010 ameliorates postoperative ileus
Published Date
Mar 1, 2020
Volume
123
Pages
109773 - 109773
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