IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia

Volume: 16, Issue: 1
Published: Dec 1, 2019
Abstract
Background Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have previously shown that sustained expression of IL-1β in the hippocampus of APP/PS1 mice decreases amyloid plaque burden independent of recruited CCR2 + myeloid cells, suggesting resident microglia as the main phagocytic effectors...
Paper Details
Title
IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
Published Date
Dec 1, 2019
Volume
16
Issue
1
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