IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
Abstract
Background Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have previously shown that sustained expression of IL-1β in the hippocampus of APP/PS1 mice decreases amyloid plaque burden independent of recruited CCR2 + myeloid cells, suggesting resident microglia as the main phagocytic effectors...
Paper Details
Title
IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
Published Date
Dec 1, 2019
Journal
Volume
16
Issue
1
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