Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan

Volume: 106, Issue: 1, Pages: 196 - 207
Published: Dec 19, 2019
Abstract
Immune thrombocytopenia is a common bleeding disease caused by autoantibody-mediated accelerated platelet clearance and impaired thrombopoiesis. Accumulating evidence suggests that desialylation affects platelet life span in immune thrombocytopenia. Herein, we report on novel effector functions of autoantibodies from immune thrombocytopenic patients which might interfere with the clinical picture of the disease. Data from our study show that a...
Paper Details
Title
Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan
Published Date
Dec 19, 2019
Volume
106
Issue
1
Pages
196 - 207
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