Engineering protein assemblies with allosteric control via monomer fold-switching.
Abstract
The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite enormous interest, the design of nanoscale allosteric assemblies has proven tremendously challenging. Here we present a proof of concept of allosteric assembly in which an engineered fold switch on the protein monomer triggers or blocks assembly. Our design is based on the hyper-stable, naturally monomeric...
Paper Details
Title
Engineering protein assemblies with allosteric control via monomer fold-switching.
Published Date
Dec 13, 2019
Journal
Volume
10
Issue
1
Pages
5703 - 5703
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Notes
History