Invited Commentary: Learning From Our Past to Build on Our Future— Lessons Learned From MRFIT and JUMBO

We propose that Blackburn (Am J Epidemiol. 2020;189(6):491–498) ignores several important issues that need to be considered in the context of a historical reflection of the National Heart Institute’s landmark study, the Multiple Risk Factor Intervention Trial (MRFIT), and the alternative proposal, the “JUMBO” trial, submitted to the National Heart Institute by an experienced team of extramural investigators but never funded. A key focus of this...