Development of a rat and human PBPK model for bromate and estimation of human equivalent concentrations in drinking water
Abstract
A physiologically based pharmacokinetic (PBPK) model was developed to described uptake, disposition and clearance of bromate in the rat using published experimental data in rat. The rodent bromate model was extrapolated to human using species-specific physiological parameters and standard interspecies scaling of rate constants. The bromate model is kinetically linear (i.e. AUC and Cmax) across the range of drinking water concentrations used in...
Paper Details
Title
Development of a rat and human PBPK model for bromate and estimation of human equivalent concentrations in drinking water
Published Date
Dec 18, 2019
Pages
1 - 12
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