CGLFold: a contact-assistedde novoprotein structure prediction using global exploration and loop perturbation sampling algorithm

Motivation Regions that connect secondary structure elements in a protein are known as loops, whose slight change will produce dramatic effect on the entire topology. This study investigates whether the accuracy of protein structure prediction can be improved using a loop-specific sampling strategy. Results A novel de novo protein structure prediction method that combines global exploration and loop perturbation is proposed in this study. In the...