Hypoglycaemia in patients with type 1 SMA: an underdiagnosed problem?

There has been increasing evidence that hyperglycaemia, hypoglycaemia and other metabolic abnormalities may occur in the severe end of the spectrum of type 1 spinal muscular atrophy (SMA). An increase in alpha cell number in pancreatic islet composition has been described in SMA knockout mice and in patients with type 1 SMA.1 Recent care recommendations suggest that prolonged fasting should be avoided in order to prevent the risk of...