Design, synthesis and anticancer evaluation of β-carboline-1-one hydantoins
Abstract
Aim: Cancer is a major health burden and a leading cause of death worldwide. We sought to discover potential anticancer molecules with novel scaffold for further development of more active agents to address the issue. Methodology: A series of β-carboline-1-one hydantoins were designed according to a conformational restriction strategy, synthesized via a one-pot Knoevenagel condensation-intramolecular cyclization, and tested in cytotoxicity...
Paper Details
Title
Design, synthesis and anticancer evaluation of β-carboline-1-one hydantoins
Published Date
Feb 1, 2020
Journal
Volume
12
Issue
3
Pages
183 - 192
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Notes
History