Improvement of the Anticancer Activities of Telmisartan by Zn(II) Complexation and Mechanisms of Action

Volume: 197, Issue: 2, Pages: 454 - 463
Published: Dec 20, 2019
Abstract
To improve the anticancer activity of telmisartan, its structure has been modified by Zn(II) complexation giving [Zn(Telm)2(H2O)2]·2H2O (ZnTelm). The cytotoxic effect was measured on the human lung cancer cells (A549) and on the lung fibroblast cells (MRC-5). The complex markedly improved anticancer activity (IC50 75 μM) of telmisartan (IC50 125 μM) or ZnSO4 (IC50 225 μM) and did not show toxicity on non-cancer cells, inducing oxidative stress...
Paper Details
Title
Improvement of the Anticancer Activities of Telmisartan by Zn(II) Complexation and Mechanisms of Action
Published Date
Dec 20, 2019
Volume
197
Issue
2
Pages
454 - 463
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