Improvement of the Anticancer Activities of Telmisartan by Zn(II) Complexation and Mechanisms of Action
Abstract
To improve the anticancer activity of telmisartan, its structure has been modified by Zn(II) complexation giving [Zn(Telm)2(H2O)2]·2H2O (ZnTelm). The cytotoxic effect was measured on the human lung cancer cells (A549) and on the lung fibroblast cells (MRC-5). The complex markedly improved anticancer activity (IC50 75 μM) of telmisartan (IC50 125 μM) or ZnSO4 (IC50 225 μM) and did not show toxicity on non-cancer cells, inducing oxidative stress...
Paper Details
Title
Improvement of the Anticancer Activities of Telmisartan by Zn(II) Complexation and Mechanisms of Action
Published Date
Dec 20, 2019
Volume
197
Issue
2
Pages
454 - 463
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