Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes
Abstract
Deubiquitinating enzymes (DUBs) function to remove or cleave ubiquitin from post-translationally modified protein substrates. There are about 100 known DUBs in the proteome, and their dysregulation has been implicated a number of disease states, but the specific function of many subclass members remains poorly understood. Activity-based probes (ABPs) react covalently with an active site residue to report on specific enzyme activity, and thus...
Paper Details
Title
Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes
Published Date
Dec 18, 2019
Journal
Volume
7
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