ADP-ribosylation: from molecular mechanisms to human disease
Abstract
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss...
Paper Details
Title
ADP-ribosylation: from molecular mechanisms to human disease
Published Date
Jan 1, 2020
Volume
43
Issue
1 suppl 1
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