Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening

Biomarkers are of interest to identify patients at risk for peri‐implant osteolysis and aseptic loosening. We used a rat model of particle‐induced peri‐implant osteolysis to investigate if early changes in biomarkers were associated with subsequent implant fixation strength. Implants were placed in rat femora, which were then challenged with intra‐articular knee injections of either clean polyethylene, lipopolysaccharide‐doped polyethylene, or...