HRP2: Transforming Malaria Diagnosis, but with Caveats

HRP2 detection forms the basis of the most sensitive mRDTs currently available, and HRP2-based mRDTs have been the central element in the scale-up of mRDTs over the last decade, allowing malaria diagnosis even in remote areas in sub-Saharan African. Over 1 billion mRDTs have been sold so far.Parasites with HRP2 deletion were first reported from the Amazon region (Peru and neighbouring countries) in 2010 and, more recently, at high prevalence in...