Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer
Abstract
Metastasis, the development of secondary malignant growths at a distance from a primary tumor, is the cause of death for 90% of cancer patients, but little is known about how metastatic cancer cells adapt to and colonize new tissue environments. Here, using clinical samples, patient-derived xenograft (PDX) samples, PDX cells, and primary/metastatic cell lines, we discovered that liver metastatic colorectal cancer (CRC) cells lose their...
Paper Details
Title
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer
Published Date
Dec 6, 2019
Journal
Volume
30
Issue
1
Pages
34 - 49
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