The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan
Abstract
The AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by sensing the metabolic status of the cell. AMPK is regulated by phosphorylation and dephosphorylation as a result of changing AMP/ATP levels and by removal of inhibitory ubiquitin residues by USP10. In this context, we identified the GID-complex, an evolutionarily conserved ubiquitin-ligase-complex (E3), as a negative regulator of AMPK activity. Our data show that...
Paper Details
Title
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan
Published Date
Dec 3, 2019
Journal
Volume
16
Issue
9
Pages
1618 - 1634
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