Rescue of TCA Cycle Dysfunction for Cancer Therapy
Abstract
Mitochondrion, a maternally hereditary, subcellular organelle, is the site of the tricarboxylic acid (TCA) cycle, electron transport chain (ETC), and oxidative phosphorylation (OXPHOS)—the basic processes of ATP production. Mitochondrial function plays a pivotal role in the development and pathology of different cancers. Disruption in its activity, like mutations in its TCA cycle enzymes, leads to physiological imbalances and metabolic shifts of...
Paper Details
Title
Rescue of TCA Cycle Dysfunction for Cancer Therapy
Published Date
Dec 6, 2019
Journal
Volume
8
Issue
12
Pages
2161 - 2161
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Notes
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