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Significant group-level hotspots found in deep brain regions during transcranial direct current stimulation (tDCS): A computational analysis of electric fields

Published on Mar 1, 2020in Clinical Neurophysiology3.675
· DOI :10.1016/J.CLINPH.2019.11.018
Jose Gomez-Tames8
Estimated H-index: 8
(Nagoya Institute of Technology),
Akihiro Asai2
Estimated H-index: 2
(Nagoya Institute of Technology),
Akimasa Hirata34
Estimated H-index: 34
(Nagoya Institute of Technology)
Abstract
Abstract Objective Transcranial direct current stimulation (tDCS) is a neuromodulation scheme that delivers a small current via electrodes placed on the scalp. The target is generally assumed to be under the electrode, but deep brain regions could also be involved due to the large current spread between the electrodes. This study aims to computationally evaluate if group-level hotspots exist in deep brain regions for different electrode montages. Methods We computed the tDCS-generated electric fields (EFs) in a group of subjects using interindividual registration methods that permitted the projection of EFs from individual realistic head models (n = 18) to a standard deep brain region. Results The spatial distribution and peak values (standard deviation of 14%) of EFs varied significantly. Nevertheless, group-level EF hotspots appeared in deep brain regions. The caudate had the highest field peaks in particular for F3-F4 montage (70% of maximum cortical EF), while other regions reach field peaks of 50%. Conclusions tDCS at deeper regions may include not only modulation via underlying cortical or subcortical circuits but also modulation of deep brain regions. Significance The presented EF atlas in deep brain regions can be used to explain tDCS mechanism or select the most appropriate tDCS montage.
  • References (80)
  • Citations (5)
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References80
Newest
#1Jose Gomez-Tames (Nagoya Institute of Technology)H-Index: 8
#2Atsushi Hamasaka (Nagoya Institute of Technology)H-Index: 2
Last. Shoogo Ueno (UTokyo: University of Tokyo)H-Index: 36
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Deep transcranial magnetic stimulation (dTMS) is a non-invasive technique used for the treatment of depression and obsessive compulsive disorder. In this study, we computationally evaluated group-level dosage for dTMS to characterize the targeted deep brain regions to overcome the limitations of using individualized head models to characterize coil performance in a population. We used an inter-subject registration method adapted to the deep brain regions that enable projection of computed electr...
2 CitationsSource
#1Essam A. Rashed (Suez Canal University)H-Index: 7
#2Jose Gomez-Tames (Nagoya Institute of Technology)H-Index: 8
Last. Akimasa Hirata (Nagoya Institute of Technology)H-Index: 34
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Abstract The development of personalized human head models from medical images has become an important topic in the electromagnetic dosimetry field, including the optimization of electrostimulation, safety assessments, etc. Human head models are commonly generated via the segmentation of magnetic resonance images into different anatomical tissues. This process is time consuming and requires special experience for segmenting a relatively large number of tissues. Thus, it is challenging to accurat...
7 CitationsSource
#1Daria Antonenko (Humboldt University of Berlin)H-Index: 16
#2Axel Thielscher (DTU: Technical University of Denmark)H-Index: 33
Last. Agnes Flöel (Humboldt University of Berlin)H-Index: 7
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Abstract Background Recent research on neural and behavioral consequences of transcranial direct current stimulation (tDCS) has highlighted the impact of individual factors, such as brain anatomy which determines current field distribution and may thus significantly impact stimulation effects. Computational modeling approaches may significantly advance our understanding of such factors, but the association of simulation-based tDCS-induced fields and neurophysiological outcomes has not been inves...
17 CitationsSource
#1Jose Gomez-Tames (Nagoya Institute of Technology)H-Index: 8
#2Akihiro Asai (Nagoya Institute of Technology)H-Index: 2
Last. Akimasa Hirata (Nagoya Institute of Technology)H-Index: 34
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OBJECTIVE: Cerebellar transcranial direct current stimulation (ctDCS) is a neuromodulation scheme that delivers a small current to the cerebellum. In this work, we computationally investigate the distributions and strength of the stimulation dosage during ctDCS with the aim of determining the targeted cerebellar regions of a group of subjects with different electrode montages. APPROACH: We used a new inter-individual registration method that permitted the projection of computed electric fields (...
11 CitationsSource
#1Essam A. Rashed (Nagoya Institute of Technology)H-Index: 7
#2Jose Gomez-Tames (Nagoya Institute of Technology)H-Index: 8
Last. Akimasa Hirata (Nagoya Institute of Technology)H-Index: 34
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In several medical applications as well as human safety evaluation, accurate electromagnetic field exposure assessments are required to identify potential side/adverse effects on humans. Computational human models representing anatomy are commonly used to conduct computational dosimetry studies to assess the in situ electric field for quantitative evaluation due to a limitation in conventional human models. The limitation in conventional human models was due to a limited model resolution (typica...
6 CitationsSource
#1Ilkka Laakso (Aalto University)H-Index: 21
#2Marko Mikkonen (Aalto University)H-Index: 6
Last. Satoshi Tanaka (Hamamatsu University)H-Index: 30
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The effects of transcranial direct current stimulation (tDCS) on motor cortical excitability are highly variable between individuals. Inter-individual differences in the electric fields generated in the brain by tDCS might play a role in the variability. Here, we explored whether these fields are related to excitability changes following anodal tDCS of the primary motor cortex (M1). Motor evoked potentials (MEPs) were measured in 28 healthy subjects before and after 20 min sham or 1 mA anodal tD...
24 CitationsSource
#1Yu Huang (CUNY: City University of New York)H-Index: 14
#2Lucas C. Parra (CUNY: City University of New York)H-Index: 54
Abstract To reach a deep target in the brain with transcranial electric stimulation (TES), currents have to pass also through the cortical surface. Thus, it is generally thought that TES cannot achieve focal deep brain stimulation. Recent efforts with interfering waveforms and pulsed stimulation have argued that one can achieve deeper or more intense stimulation in the brain. Here we argue that conventional transcranial stimulation with multiple current sources is just as effective as these new ...
21 CitationsSource
Abstract Background Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample including patient data. Methods We used 38 head models created from structural magnetic resonance imaging data of 19 healthy adults and 19 MDD patients and applied computati...
21 CitationsSource
#1Pratik Y. Chhatbar (MUSC: Medical University of South Carolina)H-Index: 12
#2Steven A. Kautz (MUSC: Medical University of South Carolina)H-Index: 46
Last. Wuwei Feng (MUSC: Medical University of South Carolina)H-Index: 19
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Abstract Background Transcranial direct current stimulation (tDCS) is a promising brain modulation technique for several disease conditions. With this technique, some portion of the current penetrates through the scalp to the cortex and modulates cortical excitability, but a recent human cadaver study questions the amount. This insufficient intracerebral penetration of currents may partially explain the inconsistent and mixed results in tDCS studies to date. Experimental validation of a transcra...
32 CitationsSource
#1Jose Gomez-Tames (Nagoya Institute of Technology)H-Index: 8
#2Atsushi Hamasaka (Nagoya Institute of Technology)H-Index: 2
Last. Yoshikazu Ugawa (Fukushima Medical University)H-Index: 51
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Abstract Background Transcranial magnetic stimulation (TMS) activates target brain structures in a non-invasive manner. The optimal orientation of the TMS coil for the motor cortex is well known and can be estimated using motor evoked potentials. However, there are no easily measurable responses for activation of other cortical areas and the optimal orientation for these areas is currently unknown. Objective This study investigated the electric field strength, optimal coil orientation, and relat...
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Cited By5
Newest
#1Ghazaleh Soleimani (AUT: Amirkabir University of Technology)
#2Mehrdad Saviz (AUT: Amirkabir University of Technology)H-Index: 6
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Two challenges to optimizing transcranial direct current stimulation (tDCS) are selecting between, often similar, electrode montages and accounting for inter-individual differences in response. These two factors are related by how tDCS montage determines the current flow through the brain considered across or within individuals. MRI-based computational head models (CHMs) predict how brain anatomy determines the electric field (EF) patterns for a given tDCS montage. Because conventional tDCS prod...
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#1Peyman Ghobadi-Azbari (Shahed University)H-Index: 2
#2Asif JamilH-Index: 7
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The combination of non-invasive brain stimulation interventions with human brain mapping methods have supported research beyond correlational associations between brain activity and behavior. Functional MRI (fMRI) partnered with transcranial electrical stimulation (tES) methods, i.e., transcranial direct current (tDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation, explore the neuromodulatory effects of tES in the targeted brain regions and their inte...
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#1Marom Bikson (CCNY: City College of New York)H-Index: 60
#2Jacek P. Dmochowski (CCNY: City College of New York)H-Index: 24
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#1Essam A. Rashed (Suez Canal University)H-Index: 7
#2Jose Gomez-Tames (Nagoya Institute of Technology)H-Index: 8
Last. Akimasa Hirata (Nagoya Institute of Technology)H-Index: 34
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Electro-stimulation or modulation of deep brain regions is commonly used in clinical procedures for the treatment of several nervous system disorders. In particular, transcranial direct current stimulation (tDCS) is widely used as an affordable clinical application that is applied through electrodes attached to the scalp. However, it is difficult to determine the amount and distribution of the electric field (EF) in the different brain regions due to anatomical complexity and high inter-subject ...
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#1Jose Gomez-Tames (Nagoya Institute of Technology)H-Index: 8
#2Atsushi Hamasaka (Nagoya Institute of Technology)H-Index: 2
Last. Shoogo Ueno (UTokyo: University of Tokyo)H-Index: 36
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Deep transcranial magnetic stimulation (dTMS) is a non-invasive technique used for the treatment of depression and obsessive compulsive disorder. In this study, we computationally evaluated group-level dosage for dTMS to characterize the targeted deep brain regions to overcome the limitations of using individualized head models to characterize coil performance in a population. We used an inter-subject registration method adapted to the deep brain regions that enable projection of computed electr...
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